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Epidemiology laboratory
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ludmila@urcrm.ru
+7(351) 232-79-18


head of the Laboratory, PhD (Medicine)
Lyudmila Krestinina


The focus of the research of the Epidemiology laboratory of the URCRM is to analyze the effect of chronic radiation exposure on the health of the residents of the Southern Urals and their offspring, including cancer incidence and mortality risk analysis, the study of non-cancer effects, as well as the influence of non-radiation factors on the values of radiation risk.

Areas of research activity:
  • study of long-term health effects of radiation exposure in the South Urals population (including obtaining direct incidence risk estimates or mortality risk estimates from various causes, correlated per unit dose)
  • dose rate factor estimation
  • analysis of quality and completeness of updated information for the cohort members, diagnose verification
  • collection of information about incidence and mortality of the Souther Urals exposed population
  • maintaining up-to-date information for the exposed population through regular data validation for the population of the catchment area
  • organization of surveys, written questionnaires, and medical examinations of the exposed residents to update information about vital status, incidence and non-radiation risk factor
The following cohorts have been created to study long-term effects of chronic radiation exposure:
  • Techa River Cohort (TRC), (~ 30 thousand people)
  • East Urals Radioactive Trace Cohort (EURTC), (~22,5 thousand people)
  • Techa River Cohort In-Utero (TRC IU), (~11,5 thousand people)
  • Southern Urals Population of Exposed Radiation (SUPER) Cohort, (~ 62 thousand people, combining TRC and EURTC (including exposed offspring).

Cohorts of persons exposed in childhood, as well as first-, second-, and third-generation offspring, are currently being formed.

The following registries have been formed in the Laboratory:

• Cancer Registry of the exposed population of the Southern Urals
• Incidence Registry of patients of the URCRM Clinical department
• Cause of death registry of the exposed population of the Southers Urals
• Registry of non-radiation risk factors.
The results of 70-year follow-up studies have provided direct estimates of incidence and mortality risk from malignant tumors and leukemia, as well as cardiovascular diseases.
  • The dependence of carcinogenic effect and cardiovascular mortality on the dose of chronic exposure, which is well described by a linear model, is proven
  • The values of Excess Relative Risk (ERR) do not contradict ERR values in other population ()
  • Величины избыточного относительного риска (ИОР) не противоречат оценкам ИОР в других популяциях (LSS cohort, Chernobyl cleanup workers cohort, cohort of Mayak PA workers, cohort of workers included in the international 15 country study)

  • The results suggest that low dose rates accumulated over a long period of exposure cause effects (calculated per unit dose) similar to those of high-dose acute exposures to which the atomic bombing survivors were exposed
  • The results of the studies are presented in the UNSCEAR Report 2018 «Epidemiological studies of cancer risk due to low-dose-rate radiation from environmental sources». https://www.unscear.org/unscear/en/publications/2017.html

Stuff:

Head of the Laboratory, PhD (Medicine) – Lyudmila Krestinina
Senior researcher, PhD (Medicine - Sergey Shalaginov
Senior researcher, PhD (Medicine) - Lyudmila Mikryukova
Junior researcher - Stanislav Silkin
Senior engineer - Svetlana Epiphanova
Engineer - Larisa Sitnikova
Senior laboratory technician - Elena Ershova
Senior laboratory technician - Nina Nefyodova
Sтenior laboratory technician - Daniil Zavyalov
Technician - Olga Kazakova