Experimental Department

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Experimental department

Head of the Department
Evgeny Pryakhin

The experimental department conducts research on the effects of ionizing and non-ionizing radiation on experimental biological systems, as well as the development of approaches to correct their adverse effects. Экспериментальный отдел проводит исследования влияния ионизирующих и неионизирующих излучений на экспериментальные биологические системы, а также разработку подходов для коррекции их неблагоприятных последствий.

Areas of research activity:

radiobiological, toxicological, radioecological laboratory and field experimental studies of the effect of various factors of physical nature on biological systems at the subcellular, cellular, systemic, organismal, population, biocenotic and ecosystem levels
development of approaches to personalize radiosensitivity and risk of long-term radiation effects
development of drugs for prevention and treatment of radiation injuries
development of new radiopharmaceuticals for diagnostic and therapeutic purposes
pre-clinical examination of new drugs, cell technologies, nuclear medicine tools and technologies
development of new technologies for radiobiological research
scientific justification of radiation protection of the environment on the basis of the ecosystem approach.

Im recent years, Experimental Department has developed:

new innovative biotechnological drugs for the treatment of radiation skin lesions and acute radiation syndrome;
an experimental model to study the effects of ionizing and non-ionizing radiation on human haematopoiesis in vivo based on xenotransplantation of human haematopoietic stem cells into mice with severe combined immunodeficiency
the main regularities of the reaction of freshwater biocenoses to chronic radiation exposure have been studied.

The main radioecological regularities and radiation-hygienic consequences of radiation accidents at the Mayak PA (radioactive contamination of the Techa River; East Urals radioactive trace; the Karachay trace) are determined

Equipment

Laboratory facility for irradiation of biological objects under controlled conditions of temperature, humidity and carbon dioxide concentration (IGRUR- 1M).
Laboratory infrastructure (rooms, glovebox, etc.) for working with open radioactive substances in Class II and III, including medical radionuclides. Specialized vehicle for transportation of radioactive samples and radionuclides for medical purposes.
Laboratory equipment for working with cell cultures: CO2 incubator GALAXY CO 170C; Climatic Chamber MEMMERT ICH270C; Laminar Air Box MARS; Laminar Air Box LAMINAR-C, centrifuges, and others.
Vivarium is a complex of clean rooms for keeping SPF animals (SCID mice).
Vivarium for conventional confinement of mice, rats, rabbits.
Laboratory complex for ICP MS spectrometric studies (Aurora-M90, Nu-Horizon and ancillary equipment).
laboratory complex for biological studies:

Лабораторный комплекс для биологических исследований: haemocytometerPentra; floe laser cytometer BD ACCURI С6; portable biochemical analyser iSTAT; liquid chromatograph LC-20 Prominence; gas chromatograph; microscopes (AXIOSCOPE A1 (Ziess); motorized AXIO IMAGER M2 (Ziess); STEREO DISCOVERY. V12 (Ziess); microscope NIKON ECLIPSE I50; and others.
Repository for storage of samples, specimens, hydrobionts from radioactively contaminated water bodies (low-temperature refrigerators UF660-86E, and others).
Expeditionary equipment for organizing and conducting field work in radioactively contaminated areas (specialized vehicle, boats, boat motors, electric generators, freezer, dosimetry equipment, portable measuring instruments).
Laboratory complex for determination of radionuclide content in samples of water, bottom sediments, biota, biological tissues and liquids (fume hoods; muffle furnaces; beta gamma scintillation spectrometer QUANTILLUS 1220; semiconductor gamma spectrometer USK, alpha spectrometers, low-background radiometers, etc.)

Лабораторный комплекс для определения содержания радионуклидов в пробах воды, донных отложений, биоты, биологических тканей и жидкостях (вытяжные шкафы; муфельные печи; сцинтилляционный бетта-гамма-спектрометр QUANTILLUS 1220; Полупроводниковый гамма-спектрометр УСК, альфа-спектрометры, радиометры низкофоновые, и др.)